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Pharmaceutical biology term index
Evolving Terminology for Emerging Technologies
Comments? Questions? Revisions? Mary Chitty mchitty@healthtech.com
Last revised March 23, 2012
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Not a comprehensive list of terms, but a quick and dirty finding aid while I'm working on getting these glossaries into a (long overdue) searchable database.
A to Z index   Glossaries & Taxonomies Site Map   How to look for other unfamiliar  terms    
Genomic biology overview    Ethics    Biomolecules    DNA    genes    RNA    Cell biology    Metabolic Engineering & Profiling    Model organisms    Nomenclature   -Omes & -omics    Proteomics    

Basic genetics & genomics
Chemistry: biochemical genomics, chemical biology, chemical genetics, chemical ligand studies, chemical space, chemogenomics, computational chemistry, dynamic medicinal chemistry, early phase drug discovery chemistry, evolutionary chemical genomics, green chemistry, materials chemistry, medicinal chemistry, metabolism- medicinal chemistry, post-genomic chemistry, privileged structures, process chemistry, structural chemogenomics
Pharmaceutical biology affinity, agonist, antagonist, antibody, antisense, binding sites, chiral, efficacy, enzymes, enzymes and coenzymes, epitope, G-protein, homologue, hormone, hydrophilicity, hydrophobicity, immunotoxins,  ligand, lipophilicity, metabolite, molarity, monoclonal antibodies, promiscuous inhibitors, receptors, recognition site, recombinant ..., solubility, substrate, vaccine

Drug safety & pharmacovigilance  ED 50, idiosyncratic toxicity, molecular toxicology, pharmacoepidemiology, phase IV post marketing surveillance, post approval drug safety, predictive ADME, predictive toxicogenomics, PSURs, susceptibility, systems toxicology, therapeutic index, tox chips, toxicogenomics, toxicoinformatics, toxicology, toxicoproteomics, toxins, xenobiotic  

Drug Targets compound ..., disease targets, drug targets, gene targeting, gene targets, GPCRs G protein coupled receptors, HDAC histone deacetylase Inhibitors,  intracellular ..., ion channels, kinases, molecular targets, nuclear hormone receptors, protein targets, target ..., target validation, tissue targeting, tractable targets

Genomics- pharmaceutical  biocomplexity, complex ..., DDBJ, DOE, EMBL, GenBank, genome ..., genomic ..., HUGO, Human Genome Project, Mendelian genetics, monogenic, NHGRI, NIGMS, penetrance, phenotype,  phenotyping, polygenic, post-genomic, RIKEN, Sanger, whole genome... 
        Genomics categories agricultural genomics, Beowulf, combinatorial, environmental, food, genome transplantation, high- throughput, industrial, intergenomics, integrative, inverse, metagenome, metagenomics,  microbial, nutrigenomics, paleogenomics, phage, plant, quantitative, synthetic, translational
Functional genomics biological process, comparative genomics, deductive genomics, function, functional ..., gene function, Gene Ontology, genome function, homolog, homology,   mutagenesis,  ortholog, orthologous, paralog, positional cloning, similarity, xenology, xenologous 

Genetic manipulation & disruption: BACs, biotechnology, cell culture, clone ..., cloning ..., copy number polymorphisms CNP, epigenetics, exon, forward genetics, gene disruption, gene interference, gene silencing, gene shuffling, gene suppression, gene targeting, gene titration, gene trapping, genetic recombination, genetic vector, genomic ..., knockdowns, knockins, knockouts,  molecular breeding, molecular display, molecular evolution, mutagenesis, nuclear transfer, peptide..., phage, phage display, plasmids, recombinant ..., reverse genomics, SELEX, shuffling, systems biology, vectors, YACs

Metabolic profiling AfCS, biochemical ..., Biopathways Consortium, cellular ...,  directed evolution, gene network..., gene regulatory..., genetic network..., metabolic ...  metabolic engineering, metabolite..., metabolism, metabolome, molecular interaction..., networks ...,  pathways ..., physiological genomics, signal transduction, whole genome
              Phylogenomics  clade, cladistics, evolutionary ..., genome prospecting, lateral genomics, molecular phylogenetics, phylogenetic ..., punctuated equilibrium, species, subtree..., super- orthologs,  systematics, ultra- paralogs

-Omes and -omics alleome, bibliome, biome, cardiogenomics, cellome, cytome, cytomics,  epigenomics, expressome, fluxome, foldome, immunomics, inflammasome,  integromics, interactome, ligandomics, localizome, metabolome, metabonomics, methylome, microbiome, morphome, nucleome, -omes, -omics, operomics, ORFeome, peptidome, peptidomics, pharmacomethylomics, phenome, phenomics, phosphatome, physiogenomics, pseudogenome, regulome, RNomics, secretome, separomics, signalome, systeome, transcriptome, transcriptomics, transductome, transgenomics,  translatome, transportome, unknome, vaccinome, variomics 

Proteomics  2D gel, annotation ..., bait, directed protein evolution, dissociator assays, functional ..., Human Plasma Proteome, interologs, ICAT, MUDpit, one- hybrid, phosphoproteome, post- proteomics, prey,  protein carbohydrate interactions, protein complexes, protein- DNA interactions, protein databases, protein dynamics, protein folding simulations, protein function, protein identification, protein informatics, protein- protein interactions, protein RNA interactions, proteome..., proteomic standards, proteomics ..., proteonomics, reverse two hybrid, Rosetta stone, shotgun scanning, subproteomes, twp-hybrid, whole proteome...,  yeast- two hybrid
   Proteomics categories activity based..., applied proteomics, biochemical proteome, bottom-up proteomics, cardioproteomics,  comparative proteomics,  computational proteomics, differential, drug,   functional, high-throughput, interaction, location,  microbial, microproteomics, mitochondrial proteome, neuroproteomics, phyloproteomics, physiological, predictive, protein pulldowns, quantitative, reverse, shotgun, targeted, tissue, topological
   Structural genomics ab initio ..., CASP, fold ...., homology..., NIGMS, protein ..., protein structure, RNA structural genomics, structural ..., structural proteomic, structure prediction, threading
       Glycosciences  carbohydrate..., glycobiology, glycomics, glyconomics, glycotechnology, oligosaccharides, saccharides 

Biomolecules  biomolecular interactions, characterization, compound, Dalton, dimer, macromolecule, -mer, mole, mol, molecular biology, molecular weight, nucleic acid, nucleotide, oligo, polymers, relative molecular mass 
Sequences, DNA & beyond 3' ..., 5' ...,ATCG, adenine, base, central dogma,  cytosine, downstream, enhancer, exteins, genetic code, guanine, inteins, LINES, promoter ..., protein ..., RNA ..., reading frames, reference sequences, reverse transcription, SINES, sequence, splice..., splicing, terminator..., thymine, transcription ..., translation, URF, UTR, upstream

DNA catalytic DNA, DNA forensics, double helix, EST Expressed Sequence Tag, genomic DNA, intergenic DNA, intragenic DNA,  intron, "junk DNA", mitochondrial DNA, non-coding DNA, ORESTES, Radio Free Genome, Experimental music unearthing the music hidden in DNA sequences  http://www.epotential.com/radiofreegenome regulatory sequence, repetitive sequences, sticky ends  
Gene definitions    alternative splicing, cDNA, cis, coding, CpG, exon, gene ..., localize, locus, operon, pleiotropy, synteny  
  Gene categories candidate genes, housekeeping genes, hypothetical genes, orphan genes, pseudogenes, regulator genes, silent genes, virulence genes
SNPs & other genetic variations alleles, genetic architecture, genetic recombination, genome scan, haploinsufficiency, idiomorphism, linkage, markers, multifactorial, multigenic, mutation, polymorphisms, population genetics, population genomics, Single Nucleotide Polymorphisms SNPs, SNP Consortium,  scanning, scoring, Single Amino acid Polymorphisms SAPs, variants
Maps genomic & genetic 2D gel maps, BAC maps, cell mapping, comparative genome mapping, contig maps, cytogenetic maps, gene map, haplotype map, HapMap,  high resolution ..., homology map, locus, mapping, physical mapping, protein interaction mapping, proteome maps, resolution, SNP maps, transcriptome maps, YAC maps 

RNA aRNA, alternative RNA splicing, cRNA, catalytic RNA, codon,  mRNA messenger RNA, RNAi RNA interference, RNA..., ribozymes, scRNA, siRNA, snRNA, snoRNA, tRNA, trans-splicing, uracil
Expression, genes & more alternative transcripts, analysis..., differential display, downregulation, expression ..., gene expression, gene regulation, guilt by association, mRNA expression, molecular..., overexpression, protein expression ..., RAGE, SAGE, TOGA, transcript... , upregulation

Proteins  amino acids, amino terminus, C-terminus, denaturation, methylation, N-terminus, peptide..., phosphorylation, post-translational modifications, primary structure, protein engineering, protein ..., subcellular localization
  Protein categories antifreeze proteins,  basic proteins, candidate proteins, cellular proteins, chemokines, complex proteins, cytokines, designer proteins, gatekeeper proteins, growth factors, housekeeping proteins, hypothetical proteins, luxury proteins, nuclear proteins, orphan proteins, polypeptides, protein kinases, putative proteins, secreted proteins, wild-type proteins, zinc finger proteins
       Protein structures3D protein structures, aggregation, domain ..., fold ..., membrane protein ..., misfolding, motif, peptide ..., protein families, protein superfamilies, quaternary, secondary, tertiary

Glycosciences carbohydrate..., glycobiology, glycomics, glyconomics, glycotechnology, oligosaccharides, saccharides 

Cell biology angiogenesis, apoptosis, cell ..., cellular ..., chromosome, clone ..., cryobiology, developmental biology, differentiation, FACS, flow cytometry, Laser Capture Microdissection, lymphokines, stem cells LCM, metabolism, NF-kappaB, ploidies, ploidy, programmed cell death, ribosomes, second messenger...,  Toll Like Receptors TLRs 

Stem cells: cell differentiation, cell research, cell therapies, cellular reprogramming, cellular therapy, differentiation, embryonic stem cells, hematopoiesis, mesenchymal, multipotent, induced pluripotent stem cell, pluripotent,  progenitor cells, stem cells, stemness, totipotent, unipotent

Metabolic engineering AfCS, biochemical ..., Biopathways Consortium, cellular ...,  directed evolution, gene network..., gene regulatory..., genetic network..., metabolic ..., metabolite..., metabolism, metabolome, molecular interaction..., networks ...,  pathways ..., physiological genomics, signal transduction, whole genome
              Phylogenomics  clade, cladistics, evolutionary ..., genome prospecting, lateral genomics, molecular phylogenetics, phylogenetic ..., punctuated equilibrium, species, subtree..., super- orthologs,  systematics, ultra- paralogs

Genetic manipulation & disruption: BACs, biotechnology, cell culture, clone ..., cloning ..., epigenetics, exon, forward genetics, gene disruption, gene interference, gene silencing, gene shuffling, gene suppression, gene targeting, gene titration, gene trapping, genetic recombination, genetic vector, genomic ..., knockdowns, knockins, knockouts,  molecular breeding, molecular display, molecular evolution, mutagenesis, nuclear transfer, peptide..., phage, phage display, plasmids, recombinant ..., reverse genomics, SELEX, shuffling, systems biology, vectors, YACs

Model & other organisms animal model, Arabidopsis, C. elegans, Drosophila, E. Coli, GMO, model organisms, mouse, rat, Saccharomyces cerevisae, transgenic, virtual organism, Xenopus, yeast, zebrafish 

Nomenclature, genes, proteins & species carbohydrate, enzyme, gene, human gene, protein, species

Bibliography
Alpha glossary index
How to look for other unfamiliar  terms