Applications  Map: Finding guide to terms in these glossaries  Site Map Related glossaries include Protein informatics   Protein Technologies  Proteomics,  Proteins,  Protein categories,  Protein Structures

absolute proteomics:  Nature Biotechnology 23(5): vii, May 2005

applied proteomics:  Many current applications of proteomics seem to be focusing on toxicology and drug target identification and target validation.  Related terms: Drug discovery & development, Targets

biochemical proteome: An analysis of the genomic sequences of many organisms indicates that a large fraction of the encoded proteins cannot be assigned particular molecular and/or cellular functions. Since the molecular function of a gene product is tightly coupled to its three-dimensional structure, determining the structure or its folding pattern may provide important insight into its molecular function, which, in turn, may help to place it in a particular cellular pathway. However, structure determination and the experimental verification of the molecular function inferred by the structure require cloning and expression of the genes, and purification of the proteins in the proteome, the protein complement of a genome. Biochemical and molecular biological approaches are used to develop high throughput methods for determining structure- function relationship of a proteome. Rosalind Kim, Physical Biosciences Division, Lawrence Berkeley National Lab, US http://pbd.lbl.gov/PBD_web_site/web_site/html/about/people/kim-r.html 

biochemical proteomics: Represents a straightforward approach to find the biochemical function of unknown genes by direct analysis of biochemical activity of the purified protein … In a pioneering study that laid the basis of biochemical proteomics approach, Phizicky and co-workers screened pools of purified yeast proteins for specific enzymatic activities (Martzen et al., 1999, Science, 286: 1153-1155; Phizicky et al., 2003, Nature, 422: 208-215). We have developed a complementary approach that is based on the use of general enzymatic assays to screen individually purified proteins for enzymatic activity (Kuznetsova et al., FEMS Microbiol. Rev., 2005, 29: 263-279). Yeast Integrative Biology Project  Genome Canada funded, University of Toronto http://yeastgenomics.ca/structure  Google = about 25 Sept. 10, 2003; about 140 Nov 13, 2006

chemical proteomics, chemiproteomics: Chemistry & biology glossary  
chemoproteomics: -Omes & -omics glossary
clinical proteomics: Molecular Medicine glossary

expression proteomics: Expression glossary

glycoproteomics: Glycosciences glossary Google - about 282 Sept. 10, 2003

microproteomics: Google - about 29 Sept. 10, 2003; about 43 May 9, 2005

molecular (and cellular) proteomics: The accelerating determination of genome sequences and their interpretation (genomics) has brought with it one of the most daunting challenges to modern bioscience--the concomitant determination of the structure, function, and expression of the corresponding proteins encoded therein. The magnitude of this task is staggering. The difficulties arise at many stages, ranging from protein isolation and identification to structure determination, protein/protein interactions and gene expression, and the answers will require both existing technologies and methods yet to be developed. … contributions that describe the structural and functional properties of proteins and their expression, particularly with respect to developmental time courses. Emphasis will be placed on determining how the presence or absence of proteins affect biological responses, and how the interaction of proteins with germane cellular partners allows them to function. .. technological advances have an important role in a field that is still being developed and significant advances in methodology will be deemed to be appropriate subject matter too. The inclusion of array technologies that measure changes in mRNA levels (as opposed to other arrays) can be viewed as the interface between genomics and proteomics. However, the important predictive value of this information with respect to subsequent changes in expression of the proteins themselves suggests that this area of investigation also falls within the proposed scope of the journal. It is also important to recognize that a significant part of the work on proteomics for the foreseeable future will reflect calculations and/or predictions as opposed to experimental data.  Scope note Molecular and Cellular Proteomics http://www.mcponline.org/site/home/about/index.xhtml   "molecular proteomics" Google - about 377 Sept. 10, 2003; about 205 June 15, 2007 Related/equivalent term?: interaction proteomics

pharmacoproteomics:   Pharmacogenomics glossary. Google - about 399 Sept. 10, 2003

riboproteomics: Omes & omics glossary

tissue proteomics:  The National Cancer Institute and the Food & Drug Administration are funding a multimillion dollar ''Tissue Proteomics Initiative'' to identify proteins linked to early stages of colon, breast, and other cancers. ["Beyond the genome" Business Week Online, April 10, 2000] http://www.businessweek.com/2000/00_15/b3676117.htm  Google - about 303 Sept. 10, 2003

toponomics:  Management and interpretation of high- throughput experiments analysing protein networks of whole cells in situ, also known as topological proteomics or toponomics. MelTec generates continuously large data sets to decipher the toponome of cells and tissues by tracing out and interpreting the context of proteins in cells. management and interpretation of high- throughput experiments analysing protein networks of whole cells in situ. FIT and MelTec GmbH Form Alliance to Create Next-Generation IT Platform for Topological Proteomics, press release, 2003 http://www.fit.fraunhofer.de/medien/meltec/pm_2003-1-20.html 

Google = about 1,090 Oct. 25, 2006

toxicoproteomics: Pharmacogenomics glossary  Google - about 356 Sept. 10, 2003

Bibliography
Nature “Post-Genomics Gateway” http://www.nature.com/genomics/post-genomics/index.html
UNI-PROT KnowledgeBase keywords http://www.expasy.org/cgi-bin/keywlist.pl   Swiss Institute of Bioinformatics, Geneva Switzerland, European Bioinformatics Institute, Hinxton, UK, 
PIR Protein Information Resource, 2004, 800 + definitions.

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IUPAC definitions are reprinted with the permission of the International Union of Pure and Applied Chemistry.