SLA presentation June 10, 2002 > Genomics tour
Genomics & Informatics-quick tour
Last revised June 21, 2002 Working draft
The promise of genomics
"I think I found a corner piece!" http://cagle.slate.msn.com/news/gene/gene14.asp Human Genome cartoons, Slate magazine, US
Vision vs. "some assembly required"
Racing to the beginning of the road, Robert Weinberg, 1998 http://www.amazon.com/gp/product/product-description/0716732831/ref=dp_proddesc_0/104-2462065-1932725?ie=UTF8&n=283155
If genomics is a race, it is a marathon, not a 100 yard dash.
Genomics glossaries & taxonomies
Genomic biology overview Basic genetics & genomics Gene definitions Model & other organisms Nomenclature Pharmaceutical biology Proteins SNPs & other genetic variations Sequences More... Genomic biology map
Genetics & genomics: Whatís the
Genomics is trying to look at all the genes (and gene products - RNA and proteins) as a dynamic system, over time, determining how they interact and influence biological pathways, networks and physiology, in a much more global sense. A dynamic process, 2D vs. 3D and 4D, systems biology
genomics: Generation of information about living things by systematic approaches that can be performed on an industrial scale. [Roger Brent "Genomic biology" Cell 100: 169-183 Jan 2, 2000] Genomics glossary has more.
proteomics: The analysis of complete complements of proteins. ... proteomics now refers to any procedure that characterizes large sets of proteins. [Stanley Fields, "Proteomics in Genomeland" Science 291: 1221- 1224 Feb. 16, 2001]
Industrial scale analysis of many proteins and their interactions, over time, ultimately tying this into physiological processes and biological pathways and networks. Proteomics glossary
Beyond proteomics ? -Omes & -omics glossary
Informatics terms, concepts and skills are increasingly important.
informatics: The study of the application of computer and statistical techniques to the management of information. In genome projects, informatics includes the development of methods to search databases quickly, to analyse DNA sequence information, and to predict protein sequence and structure from DNA sequence data. [ORD Office of Rare Diseases, NIH glossary]
Narrower terms: bioinformatics, cheminformatics; clinical informatics, genome informatics, medical informatics, molecular informatics, pharmacoinformatics, pharmainformatics protein informatics, research informatics, social informatics
Ask five bioinformaticians for a definition of bioinformatics and you'll get seven definitions. Michael Liebman, Macroresults through Microarrays, April 30, 2002, Boston MA
Useful concepts: bottom-up, complexity, granularity, interoperability, just- in- time information, metadata, new paradigms, nonlinear, top- down
Ewan Birney's "disarmingly simple advice to scientists debuting in bioinformatics "Don't feel like an idiot, because everyone does when they first start" Declan Butler "Are you ready for the revolution? Nature 409 (6822): 758- 760, 15 Feb. 2001
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