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Pharmaceutical Genomic & Proteomic Manipulation & Disruption glossary & taxonomy
Evolving Terminologies for Emerging Technologies
Comments? Questions? Revisions?
Mary Chitty mchitty@healthtech.com
Last revised November 05, 2013

 



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Related glossaries include Applications: Drug discovery & development Functional genomics,   
Informatics: Bioinformatics  Cheminformatics Drug discovery Informatics Genomic InformaticProtein Informatics 
Technologies:  Bioprocessing & Manufacturing  Cell & tissue technologies   Genomic Technologies   Metabolic engineering  Protein Technologies
Biology: Cell biology  Gene definitions  GenomicsPharmaceutical biology   Proteomics  Proteins  RNA  SNPs & other genetic variations  Stem cells

aptamers: Technologies overview
biochemical genomics: Chemistry & biology

biotechnology:
Biologics 

chemical mutagenesis:  Systematic mutagenesis using chemical with mutagenic properties.

display technologies: Technologies overview
epigenetic, epigenetics:  Genetic variations & SNPs   epigenome, epigenomics: -Omes & -omics

forward genetics: The traditional approach to genetics, which starts with a phenotype and then identifies genetic mutations or variations that control or cause that trait. CHA, Cambridge Healthtech Advisors Model Animal Systems: Emerging Applications and Commercial Opportunities in Drug Discovery and Development, report, 2004 Related term: positional cloning. Compare reverse genetics

forward genomics: Large- scale insertional mutagenesis offers several significant features as a genomics platform. DNA insertions allow rapid functional analysis of phenotypes and the associated genes in a forward genomics research program. In addition, the indexed collection of insertion mutants creates basis for a robust program in reverse genomics by which one may analyze phenotypes associated with any given gene identified only by sequence. HELENA MATHEWS "Gene Discovery in Plants by Activation Tagging" In Vitro Cell. Dev. Biol - Animal 37:3 Part II, March 2001

Refers to complex interactions between DNA (transcriptional gene silencing) and RNA (post- transcriptional gene silencing) based on the homology between these sequences, their place into the genome, the possible modifications of their chemical structure, etc. These interactions may stop the expression of a gene or lead to the degradation of its transcription products (RNA), thus "silencing" the gene as no proteins are produced anymore. Barbara Bordogna, Sustainability and Public or Private Management Glossary, Univ. Geneva, 2003  http://supprem.unige.ch/glossary/   Narrower terms: Post-Transcriptional Gene Silencing PTGS, RNA silencing; Related term: epigenetics

library: Combinatorial libraries & synthesis  How does this relate to combinatorial library and related terms in Drug discovery & development (or more general meanings of  "library").  Narrower terms: gene library, genomic library;  Microarrays arrayed library; Sequencing DNA library 

molecular farming:  Related/equivalent? term: pharming  

Bibliography
DOE, Human Genome Project Information, Oak Ridge National Laboratory, Dictionary of Genetic Terms. 2007, 100+ definitions. http://www.ornl.gov/sci/techresources/Human_Genome/glossary/ 
IUPAC  International Union of Pure and Applied Chemistry, Glossary of Terms used in Bioinorganic Chemistry, Recommendations, 1997. 450+ definitions. http://www.chem.qmw.ac.uk/iupac/bioinorg/
IUPAC  International Union of Pure and Applied Chemistry, Glossary for Chemists of terms used in biotechnology. Recommendations, Pure & Applied Chemistry 64 (1): 143-168, 1992. 200 + definitions.
IUPAC International Union of Pure and Applied Chemistry, Glossary of Terms Used in Combinatorial Chemistry, D. Maclean, J. J. Baldwin, V.T. Ivanov, Y. Kato, A. Shaw, P. Schneider, and E. M.. Gordon, Pure Appl. Chem., Vol. 71, No. 12, pp. 2349-2365, 1999. 100+ definitions. http://www.iupac.org/reports/1999/7112maclean/
IUPAC  International Union of Pure and Applied Chemistry, Compendium of Chemical Terminology: Recommendations, compiled by Alan D. McNaught and Andrew Wilkinson, Blackwell Science, 1997. "Gold Book" 6500+ definitions. http://goldbook.iupac.org/  
IUPAC International Union of Pure and Applied Chemistry, Glossary of Medicinal Chemistry, 1998. 100+ terms. http://www.chem.qmw.ac.uk/iupac/medchem/
MeSH Medical Subject Headings, (PubMed Browser) National Library of Medicine, Revised annually.  250,000 entry terms, 19,000 main headings. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=MeSH&term= 
NHGRI (National Human Genome Research Institute), Talking Glossary of Genetic Terms, 100+ definitions. http://www.genome.gov/glossary.cfm Includes extended audio definitions.
RNAi Gateway, BioMedCentral http://www.biomedcentral.com/gateways/RNAi 
Schlindwein Birgid, Hypermedia Glossary of Genetic Terms, 2006. 670 definitions. http://www.weihenstephan.de/~schlind/index.html
Systems Biology Gateway, BioMedCentral http://www.biomedcentral.com/gateways/systemsbiology/ 

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IUPAC definitions are reprinted with the permission of the International Union of Pure and Applied Chemistry.  

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